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Recombinant Mouse Insulin-like Growth factor-1

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132594-10 μg 0 ￥1800 请登录
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1308132594-50 μg 0 ￥3800 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Mouse Insulin-like Growth factor-1 是一种促有丝分裂的细胞因子。
Synonyms
rMuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I ; 重组小鼠胰岛素样生长因子-1
Species
Mouse

Source
E. coli

Accession
P05017

Gene ID
16000

Molecular Weight
Approximately 7.8 kDa

AA Sequence
MGPETLCGAE LVDALQFVCG PRGFYFNKPT GYGSSIRRAP QTGIVDECCF RSCDLRRLEM YCAPLKPTKA A

Biological Activity
The ED50 is <10 ng/mL as measured by FDC-P1 cells, corresponding to a specific activity of >1 × 105 units/mg.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Murine Insulin-like Growth factor-1 (rMuIGF-1) to 100 µg/mL using ddH2O.

Storage & Stability
Lyophilized recombinant Murine Insulin-like Growth factor-1 (rMuIGF-1) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Insulin-like growth factor (IGF) system has been shown to modulate growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone. Insulin-like Growth factor-1 (IGF-I) is produced by osteoblasts, and its mitogenic effects are mediated by their binding to the IGF plasma membrane receptors. The IGF type 1 receptor binding to both IGF-I and IGF-II, is thought to be the predominate receptor involved in mediating the effects of these growth factors in most cell types, including osteoblasts[1]. Insulin-like growth factor-1 (IGF-1) is a neurotrophic factor capable of mediating neuroprotective and neuroplasticity mechanisms. Targeted overexpression of IGF-1 enhances the generation of hippocampal newborn neurons in brain-injured mice[2].
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