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Recombinant Mouse TGF-beta 1/TGFB1 (HEK293-expressed)
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| 性状 | Recombinant Mouse TGF-beta 1/TGFB1 (HEK293-expressed) 是一种多功能细胞因子，其控制许多生物过程，包括免疫，分化，肿瘤抑制，肿瘤转移，衰老，迁移，伤口愈合，细胞凋亡，细胞分裂，脂肪生成和成骨。
Synonyms rMuTGF-beta 1/TGFB1; Transforming growth factor beta-1; TGF-β1; LAP Species Mouse Source HEK 293 Accession P04202 Gene ID 21803 Molecular Weight Approximately 12.8 kDa AA Sequence ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASASPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS Biological Activity The ED50 is <0.2 ng/mL as measured by mouse HT-2 cells. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against 4 mM HCl. Endotoxin Level <1 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Murine TGF-beta 1/TGFB1 (HEK293-expressed) (rMuTGF-beta 1/TGFB1) to 100 µg/mL using ddH2O. Storage & Stability Lyophilized recombinant Murine TGF-beta 1/TGFB1 (HEK293-expressed) (rMuTGF-beta 1/TGFB1) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background TGFβ1 regulates cell proliferation, growth, differentiation and cells movement. TGFβ1 also has immunomodulatory and profibrogenic effects. Lack of TGFβ1-dependent growth control may result in oncogenesis: papillary, follicular and anaplastic thyroid cancers, prostate, breast and uterine cervical cancer, oesophagus, gastric, colorectal and liver cancers, NSCLC, and malignant melanoma. Excessive TGFβ1 activity is an integral part of the fibrotic processes occurring in the response to injury[1]. TGFβ1 can induce renal fibrosis via activation of both canonical (Smad-based) and non-canonical (non-Smad-based) signalling pathways, which result in activation of myofibroblasts, excessive production of extracellular matrix (ECM) and inhibition of ECM degradation[2]. TGF-β1 induces anti-inflammatory regulatory T cells (Treg), and inflammatory T helper 17 (Th17) cells in combination with interleukin-6[3]. |
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- Recombinant Mouse TGF-beta 1/TGFB1 (HEK293-expressed)
- Recombinant Human Transforming Growth Factor β1
- Recombinant Human Transforming Growth Factor β2
- Recombinant Human Transforming Growth Factor beta3 (HEK293-expressed)
- Recombinant Human Hepatocyte Growth Factor (CHO-expressed)
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