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INSR / IGF-R Phospho (pY1185)
英文名：INSR / IGF-R Phospho (pY1185)
Cas号：
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检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308114451-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | INSR antibody, CD220 antibody, HHF5 antibody, Insulin receptor subunit beta antibody, antibody |
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| 产品参数 | 【产品介绍】The insulin receptor is an essential
protein present on the surface of virtually all cells. Little is known about the control of the level of this protein on cellular surfaces, but it has been found that the level of insulin receptor protein correlates roughly with the level of insulin receptor (IR) gene transcripts within cells (1). The insulin receptor plays a critical role in the maintenance of glucose homeostasis. Regulation of this key function must be under stringent controls (2). Insulin receptor substrate 1 (IRS-1) and src homology and collagen protein (SHC) are signaling proteins which are rapidly phosphorylated on tyrosines after insulin receptor activation. It has been shown that both SHC and IRS-1 interact with the tyrosine-phosphorylated NPEY motif of the IR and insulin-like growth factor I receptor via non-SH2 domains (3). Recommended Applications WB, ICC, IP Applications and Recommended Dilution Factors WB: 1:500 ICC: 1:100 - 250 IP: 1:20 Species Reactivity * Human *Cross reactivity determined by western blot only. Products Data A. Western blot analysis on HepG2 cell lysates using anti-Phospho-INSR/IGF-R (pY1185) RabMAb (cat. #2182-1), 1:500 dilution. Cells were either (A) untreated or (B) treated with insulin. Specificity A phospho synthetic peptide corresponding to residues surrounding Tyrosine 1185 of human INSR was used as an immunogen. This antibody detects INSR phosphorylated at Tyrosine 1185. |
| 性状 | 【产品类型】Rabbit Monoclonal Antibody
【反应特异性】Human 【克隆 ID】EP351(2)Y 【用途】WB , ICC , IP 【产品性状】 【阳性对照】 【产品浓度】 【细胞定位】 【抗原分子量】95kDa |
| 贮存 | Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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