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Recombinant Human AG-2, His (HEK293-expressed)

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132986-10 μg 0 ￥3200 请登录
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1308132986-50 μg 0 ￥9800 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human AG-2, His (HEK293-expressed) 是带有 N 末端 His 标签的人重组 AG-2，在 HEK293 细胞中表达。
Synonyms
rHuAG-2, His; HPC8; AGR2; AG2 ; 重组人 AG-2，His (HEK293 细胞表达)
Species
Human

Source
HEK 293

Accession
O95994

Gene ID
10551

Molecular Weight
Approximately 18.0 kDa

AA Sequence
RDTTVKPGAK KDTKDSRPKL PQTLSRGWGD QLIWTQTYEE ALYKSKTSNK PLMIIHHLDE CPHSQALKKV FAENKEIQKL AEQFVLLNLV YETTDKHLSP DGQYVPRIMF VDPSLTVRAD ITGRYSNRLY AYEPADTALL LDNMKKALKL LKTELHHHHH H

Biological Activity
Data is not available.

Appearance
Solution

Formulation
Supplied as a 0.2 μm filter solution of 20 mM Tris, 200 mM NaCl, 10% Glycerol, pH 8.0.

Endotoxin Level
<1 EU/μg, determined by LAL method.

Reconstitution
N/A

Storage & Stability
Recombinant Human AG-2, His (HEK293-expressed) (rHuAG-2, His) is stored at -20°C. It is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Shipping with dry ice.

Background
AG-2 (Anterior gradient 2) is a human ortholog of the Xenopus laevis cement gland protein and a member of the protein disulfide isomerase (PDI) family. AG-2 is highly expressed and secreted in malignant cancer types, including breast carcinomas, pancreatic cancer, glioblastoma, prostate cancer and metastatic colorectal cancer. AGR2 is also a pro-oncogenic protein that stimulates EGFR ligand amphiregulin, regulate p53 signaling, and interact with the AAA+ protein Reptin. Overexpressed AG-2 stabilizes HIF-1α in tumor cells[1][2].
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