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Recombinant Human AGER, His (HEK293-expressed)

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132988-10 μg 0 ￥2500 请登录
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1308132988-50 μg 0 ￥6400 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human AGER, His (HEK293-expressed) 是带有 C 末端 His 标签的人重组 AGER，通过哺乳动物表达系统表达，并表达编码Ala23-Ala344的靶基因。
Synonyms
rHuAGER, His; RAGE; AGER ; 重组人 AGER，His (HEK293 细胞表达)
Species
Human

Source
HEK 293

Accession
Q15109

Gene ID
177

Molecular Weight
Approximately 55.0 kDa

AA Sequence
AQNITARIGE PLVLKCKGAP KKPPQRLEWK LNTGRTEAWK VLSPQGGGPW DSVARVLPNG SLFLPAVGIQ DEGIFRCQAM NRNGKETKSN YRVRVYQIPG KPEIVDSASE LTAGVPNKVG TCVSEGSYPA GTLSWHLDGK PLVPNEKGVS VKEQTRRHPE TGLFTLQSEL MVTPARGGDP RPTFSCSFSP GLPRHRALRT APIQPRVWEP VPLEEVQLVV EPEGGAVAPG GTVTLTCEVP AQPSPQIHWM KDGVPLPLPP SPVLILPEIG PQDQGTYSCV ATHSSHGPQE SRAVSISIIE PGEEGPTAGS VGGSGLGTLA LAHHHHHH

Biological Activity
Data is not available.

Appearance
Solution

Formulation
Supplied as a 0.2 μm filter solution of PBS, pH 7.4.

Endotoxin Level
<1 EU/μg, determined by LAL method.

Reconstitution
N/A

Storage & Stability
Recombinant Human AGER, His (HEK293-expressed) (rHuAGER, His) is stored at -20°C. It is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Shipping with dry ice.

Background
AGER (Advanced glycosylation end product-specific receptor), a member of the immunoglobulin superfamily of cell surface molecules, is a transmembrane signal transduction receptor with a number of ligands, including alarmins that can initiate and perpetuate immune responses. AGER naturally exists in two forms that are full-length membrane-bound and truncated (soluble). The human AGER is a highly polymorphic gene with more than 190 SNPs mapped to its locus on the 6p21.3 chromosome. AGER interacts with a broad spectrum of ligands and multiple signaling pathways, such as those activated by the high mobility group box 1 (HMGB1) protein (a non-canonical ligand of AGER). AGER serve as a mediator of both acute and chronic vascular inflammation in certain conditions such as atherosclerosis and in particular as a complication of diabetes[1][2].
贮存
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